The Pathology of Orthopedic Implant Failure Is Mediated by Innate Immune System Cytokines
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منابع مشابه
The Pathology of Orthopedic Implant Failure Is Mediated by Innate Immune System Cytokines
All of the over 1 million total joint replacements implanted in the US each year are expected to eventually fail after 15-25 years of use, due to slow progressive subtle inflammation at the bone implant interface. This inflammatory disease state is caused by implant debris acting, primarily, on innate immune cells, that is, macrophages. This slow progressive pathological bone loss or "aseptic l...
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Cytokines and chemokines are released from a wide range of immune cells, and are essential for the communication of signals in both innate and adaptive immunity. While there is a substantial body of literature regarding the function of cytokines and chemokines in immunity, remarkably little has been done to determine how these are packaged and secreted from a range of immune cells. Our knowledg...
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The innate immune system ; is an important subsystem of the overall immune response system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system, the system does not confer long-lasting or protective immunity to the host. Innate imm...
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Virus-specific CD8(+) T cells develop the ability to function in an "innate" capacity by responding to a remarkable array of cytokines in a TCR-independent manner. Although several cytokines such as IL-12 and IL-18 have been identified as key regulators of CD8(+) T-cell activation, the role of other cytokines and the ways in which they interact with each other remain unclear. Here, we have used...
متن کاملAn Audit of Implant Failure in Orthopedic Surgery
Objective: To determine the causes of orthopedic implants failure, which is being used in our setup for fixation of different fractures. Materials and Methods: The study was conducted at Orthopedic and Spine surgery unit of Hayatabad Medical Complex (HMC) Peshawar from November 2007 to May 2014. A total of 62 patients were retrospectively identified an included in the study. The inclusion crite...
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ژورنال
عنوان ژورنال: Mediators of Inflammation
سال: 2014
ISSN: 0962-9351,1466-1861
DOI: 10.1155/2014/185150